Test Category: Specialist BiochemistryToxicology
Investigation Name:Levetiracetam
Alias or Abbreviation:LEVET
Accreditation:UKAS Accredited ISO15189:2022:On scope
Intro:
Levetiracetam is the non-branded name for the broad spectrum antiepileptic drug Keppra, which is affective against partial and generalised seizures. Dose changes of Levetiracetam produce a predictable change in serum concentration in most patients. TDM for levetiracetam is only usually required in: Children <10 years old, as clearance of Levetiracetam may be increased by as much as 60%. Patients >65 years. GFR typically falls and as a result Levetiracetam clearance may be significantly reduced by up to 40%.Pathology Laboratory:Toxicology Lab
Requestable Seperately?Yes
Units:mg/L
Minimum Sample Volume:1mL plasma/serum
Expected Turnaround Time:7 working days post sample receipt.
Test Code:LEVE
Sample Type:
A minimum of 1mL of plasma/serum collected immediately prior to next dose, or minimum of 6 hours post dose.Complex Reference Range:Non-compliance, suboptiman dose: <10 mg/L
Maximum drug efficacy: 10-40 mg/L
(Trough specimen taken pre dose or minimum of 6 hours post dose).
Referred to Another Laboratory?No
Storage Requirements:Samples should be stored at 4°C prior to sending.
Posting Address / Requirements:Ambient temperature, 1st class post.
Sandwell Health Campus
Pathology Department
Specialist Chemistry
Lyndon,
B71 4HJ
NPEX / PDF Reporting Available:NPEX and PDF reporting available.
EQA Scheme:The laboratory is enrolled on an EQA scheme with LGC Standards PT schemes and receive samples monthly.
Lead Contact Details:Lauren Starbrook, Consultant Clinical Scientist,
Email: lauren.starbrook@nhs.net
Email Address For Chasing Results:rwh-tr.bcpsspecialistchemistryenquiries@nhs.net
Site Sample Tested:City Health Campus
Cost:Please email: bcpspathology.info@nhs.net for further details
Contact Number:0121 507 4138
