Beta- 2-Glycoprotein-1 Antibody (IgM) - Black Country Pathology Services

Investigation Name:Beta- 2-Glycoprotein-1 Antibody (IgM)

Alias or Abbreviation:B2GP1 IgM

Intro:

Indication: Antiphospholipid syndrome (APS) and to evaluate the thrombotic risk in patients with systemic lupus erythematosus (SLE). Further information: NOTE: Tests available for both IgG and IgM assays and should be requested separately. Beta-2-Glycoprotein 1 (also known as apolipoprotein H) is a 50Kda beta-2-globulin found to inhibit the intrinsic coagulation pathway. Anti-B2GP1 antibodies are associated with antiphospholipid syndrome where patients suffer from venous and arterial thrombosis particularly in recurrent unexplained thrombocytopenia, recurrent foetal loss, myocardial infarction and recurrent stroke. These symptoms are often present in cases of systemic lupus erythematosus (SLE) and in many other conditions.

Requestable Seperately?Yes

Minimum Sample Volume:1mL

Test Code:B2IM

Sample Type:

Serum Gel Tube (Gold top)/ Plasma

Complex Reference Range:<7 U/mL = Negative

Collection Conditions / Other Information:1st class post or Transport

Referred to Another Laboratory?No

Storage Requirements:Ambient temperature

NPEX / PDF Reporting Available:Yes

EQA Scheme:Yes

Lead Contact Details:rwh-tr.bcpsimmunologyclinicalqueries@nhs.net

Email Address For Chasing Results:rwh-tr.ImmunologyLab@nhs.net

Methodology:Fluoroenzymeimmunoassay

UKAS Reference Number:9580 (recommended)

Site Sample Tested:Immunology, New Cross Hospital, Wolverhampton

Minimum Request Interval (MRI):180 days (6 months) over 16y only